Open Access血清载脂蛋白B与中国中老年人代谢综合征风险增加相关:一项横断面和前瞻性队列研究
Author(s) -
Du Rui,
Wu Xueyan,
Peng Kui,
Lin Lin,
Li Mian,
Xu Yu,
Xu Min,
Chen Yuhong,
Li Donghui,
Lu Jieli,
Bi Yufang,
Wang Weiqing,
Ning Guang
Publication year - 2019
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12904
Subject(s) - medicine , metabolic syndrome , odds ratio , overweight , prospective cohort study , apolipoprotein b , diabetes mellitus , confidence interval , cohort , population , cohort study , obesity , risk factor , cross sectional study , endocrinology , cholesterol , environmental health , pathology
Background Serum apolipoprotein (apo) B has been associated with an increased risk of atherosclerotic cardiovascular diseases. However, findings on the association between apoB and the risk of metabolic syndrome (MetS) are inconsistent. The purpose of this study was to investigate the association between serum apoB and MetS risk in Chinese population. Methods A baseline survey was conducted in a population‐based cohort of 10 340 adults aged ≥40 years in Shanghai, China, in 2010. A follow‐up visit was conducted to assess incident diabetes in 2015. Results At baseline, 2794 of 10 340 participants (27.02%) had MetS. Serum apoB was significantly associated with an increased risk of prevalent MetS. Multivariable‐adjusted odds ratios and 95% confidence intervals (CIs) for quintiles 2‐5 compared with quintile 1 (reference) were 1.29 (1.02‐1.63), 1.47 (1.18‐1.84), 1.32 (1.06‐1.65), and 2.02 (1.61‐2.51), respectively ( P trend < 0.05). During an average of 5.1 years follow‐up, 4627 individuals without MetS at baseline showed a significant association between apoB and the risk of incident MetS. Multivariable‐adjusted risk ratios (95% CIs) for subjects in apoB quintiles 2‐5 compared with the reference were 1.43 (1.13‐1.82), 1.57 (1.25‐1.98), 1.74 (1.38‐2.18), and 2.07 (1.66‐2.58), respectively ( P trend < 0.05). Stratified analysis suggested that the above association was much stronger among normal weight individuals than in those who were overweight or obese. Conclusion These cross‐sectional and prospective studies provide evidence that serum apoB is associated with existing MetS and is a possible predictor of the risk of MetS, especially among normal weight individuals.