Open Access甘油三酯:高密度脂蛋白胆固醇比值和2型糖尿病风险之间的剂量反应关系:中国农村人群队列和meta分析
Author(s) -
Cheng Cheng,
Liu Yu,
Sun Xizhuo,
Yin Zhaoxia,
Li Honghui,
Zhang Ming,
Zhang Dongdong,
Wang Bingyuan,
Ren Yongcheng,
Zhao Yang,
Liu Dechen,
Zhou Junmei,
Liu Xuejiao,
Liu Leilei,
Chen Xu,
Liu Feiyan,
Zhou Qionggui,
Hu Dongsheng
Publication year - 2019
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12836
Subject(s) - medicine , hazard ratio , odds ratio , quartile , type 2 diabetes mellitus , confidence interval , body mass index , overweight , endocrinology , diabetes mellitus
Background High triglyceride (TG) and low high‐density lipoprotein cholesterol (HDL‐C) levels are traditional risk factors for type 2 diabetes mellitus (T2DM). This study evaluated the dose–response relationship between the TG/HDL‐C ratio and T2DM risk. Methods The study included 11 946 adults without baseline diabetes from the Rural Chinese Cohort Study. Cox proportional hazards regression was used to investigate the association between the TG/HDL‐C ratio and T2DM. The dose–response relationship was evaluated by restricted cubic spline analysis. In addition, pooled odds ratios (OR) were calculated with a random‐effects model in a meta‐analysis including the present study and another three eligible articles. Results During 2007–14, 618 patients with T2DM were identified (9.68/1000 person‐years). People in the highest TG/HDL‐C ratio quartile had a higher T2DM risk than those in the lowest quartile (adjusted hazard ratio [aHR] 2.11, 95% confidence interval [CI] 1.55–2.86); however, the association between the TG/HDL‐C ratio and T2DM was stronger in females than males (aHR 1.27 [95% CI 1.16–1.39; and 1.19 [95% CI 1.04–1.37], respectively). In body mass index‐specific analysis, the association was stronger in normal weight than overweight/obese people. The dose–response meta‐analysis showed that a 1‐unit increment in the TG/HDL‐C ratio increased the T2DM risk by 28% (95% CI 20%–36%), with a positive linear relationship ( P linear = 0.326). Conclusions The TG/HDL‐C ratio was an independent risk factor of T2DM, especially in females, and linearly increased the risk of T2DM; thus, it may be a useful indicator to identify future T2DM.