Open Access空腹血糖受损的社区老年人群三年后发生糖尿病的危险因素
Author(s) -
Zhang Wen,
Yang Xiaolong,
Han Peipei,
Ma Yixuan,
Fu Liyuan,
Jia Liye,
Yu Hairui,
Chen Xiaoyu,
Wang Lu,
Hou Lin,
Yu Xing,
Kohzuki Masahiro,
Guo Qi
Publication year - 2019
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12816
Subject(s) - medicine , impaired fasting glucose , diabetes mellitus , odds ratio , incidence (geometry) , glycemic , impaired glucose tolerance , confidence interval , grip strength , population , logistic regression , type 2 diabetes , endocrinology , physical therapy , environmental health , physics , optics
Background The aim of the present study was to examine the risk factors for developing diabetes after 3 years in an elderly Chinese suburban population with impaired fasting glucose (IFG). Methods The study population comprised residents of the Hangu area of Tianjin, China, with IFG, aged ≥60 years, who joined the national free physical examination program ( n = 328; mean [±SD] age 68.0 ±6.1 years; 48.2% men). Diabetes was defined by self‐report of a physician's diagnosis or fasting plasma glucose (FPG) ≥7.0 mmol/L; IFG was defined as FPG ≥5.6 and < 7.0 mmol/L. Risk factors of incident diabetes at the 3‐year follow‐up were analyzed individually using logistic regression analysis. Results Between baseline and the 3‐year follow‐up, 56 subjects with IFG at baseline had developed diabetes. After multivariate adjustment for demographic and clinical factors, the incidence of diabetes increased with higher FPG (odds ratio [OR] 9.30, 95% confidence interval [CI] 2.84–30.48), but decreased with the grip strength/weight ratio (OR 0.88, 95% CI 0.82–0.94). Moreover, the combination of higher FPG and lower grip strength/weight was associated with a higher incidence of diabetes than higher FPG only or lower grip strength/weight ( P < 0.05). Conclusion The present study indicates that higher FPG and lower muscle strength are associated with glycemic deterioration among subjects with IFG after 3 years. The results suggest that not only glucose levels, but also physical performance may be useful markers of the risk of diabetes in this population.