Open AccessAssociation between urinary tin concentration and diabetes in nationally representative sample of US adults
Author(s) -
Liu Buyun,
Sun Yangbo,
Lehmler HansJoachim,
Bao Wei
Publication year - 2018
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12798
Subject(s) - medicine , diabetes mellitus , national health and nutrition examination survey , odds ratio , confidence interval , quartile , urine , creatinine , logistic regression , population , urinary system , endocrinology , gastroenterology , environmental health
Background Animal studies indicate that chronic exposure to certain tin compounds induces pancreatic islet cell apoptosis and glucose intolerance. However, little is known about the health effects of environmental tin exposure in humans. Therefore, we evaluated the association of tin exposure with diabetes in a nationally representative sample of US adults. Methods We used data from a nationally representative population ( n = 3371) in the National Health and Nutrition Examination Survey 2011–14. Diabetes ( n = 605) was defined as self‐reported physician's diagnosis, HbA1c ≥6.5%, fasting plasma glucose ≥126 mg/dL, or 2‐h plasma glucose ≥200 mg/dL. Tin concentrations in urine samples were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) of diabetes and 95% confidence intervals (CIs). Results Urinary tin concentrations were higher in individuals with diabetes (weighted median 0.58 μg/L) than those without diabetes (0.39 μg/L). After adjustment for urinary creatinine and other diabetes risk factors, the OR of diabetes comparing the highest with lowest quartile of urinary tin concentrations was 1.6 (95% CI 1.0–2.6; P trend = 0.02). Conclusions Environmental tin exposure was positively and significantly associated with diabetes in US adults.