Open AccessUtility of three novel insulin resistance‐related lipid indices for predicting type 2 diabetes mellitus among people with normal fasting glucose in rural China
Author(s) -
Wang Bingyuan,
Zhang Ming,
Liu Yu,
Sun Xizhuo,
Zhang Lu,
Wang Chongjian,
Li Linlin,
Ren Yongcheng,
Han Chengyi,
Zhao Yang,
Zhou Junmei,
Pang Chao,
Yin Lei,
Feng Tianping,
Zhao Jingzhi,
Hu Dongsheng
Publication year - 2018
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12642
Subject(s) - medicine , quartile , hazard ratio , type 2 diabetes mellitus , triglyceride , endocrinology , insulin resistance , confidence interval , waist , proportional hazards model , diabetes mellitus , cholesterol , insulin , body mass index
Background Inexpensive and easily measured indices are needed for the early prediction of type 2 diabetes mellitus (T2DM) in rural areas of China. The aim of this study was to compare triglyceride glucose (TyG), visceral adiposity (VAI), and lipid accumulation product (LAP) with traditional individual measures and their ratios for predicting T2DM. Methods Data for 11 113 people with baseline normal fasting glucose in a rural Chinese cohort were followed for a median of 6.0 years. Cox proportional hazards regression was used to calculate covariate‐adjusted hazard ratios (aHRs) and 95% confidence intervals (95% CIs) and receiver operating characteristic analysis was used to compare the ability of traditional measures and TyG, VAI, and LAP at baseline to predict T2DM at follow‐up. Results Among individual measures, fasting plasma glucose (FPG) and waist circumference (WC) were strongly associated with T2DM. Of all lipid ratios, an elevated triglycerides (TG) to high‐density lipoprotein cholesterol (HDL‐C) ratio was associated the most with T2DM. Compared with the first quartiles of TyG, VAI, and LAP, their fourth quartiles were associated with T2DM for men (aHR 3.54 [95% CI 2.08–6.03], 2.89 [1.72–4.87], and 5.02 [2.85–8.85], respectively) and women (6.15 [3.48–10.85], 4.40 [2.61–7.42], and 6.49 [3.48–12.12], respectively). For predicting T2DM risk, TyG, VAI, and LAP were mostly superior to the TG: HDL‐C ratio, but did not differ from FPG and WC. Conclusions Prediction of T2DM was not improved by TyG, VAI, and LAP versus FPG or WC alone. Therefore, TyG, VAI, and LAP may not be inexpensive tools for predicting T2DM in rural Chinese people.