Open AccessAssociation of type 2 diabetes mellitus with the interaction between low‐density lipoprotein receptor‐related protein 5 ( LRP5 ) polymorphisms and overweight and obesity in rural C hinese adults
Author(s) -
Zhang Lu,
Wang Jinjin,
Zhang Ming,
Wang Guo’an,
Shen Yanxia,
Wu Dongting,
Wang Chongjian,
Li Linlin,
Ren Yongcheng,
Wang Bingyuan,
Zhang Hongyan,
Yang Xiangyu,
Zhao Yang,
Han Chengyi,
Zhou Junmei,
Pang Chao,
Yin Lei,
Zhao Jingzhi,
Luo Xinping,
Hu Dongsheng
Publication year - 2017
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12522
Subject(s) - medicine , overweight , body mass index , lrp5 , endocrinology , type 2 diabetes mellitus , type 2 diabetes , diabetes mellitus , population , cohort , obesity , genetics , biology , wnt signaling pathway , environmental health , gene
Highlights This study provides important evidence that the interaction between LRP5 and environmental factors may affect the risk of type 2 diabetes mellitus ( T2DM ). The risk of T2DM may be increased with by an interaction between LRP5 and overweight and obesity. Furthermore, LRP5 polymorphisms are related β‐cell function and lipid metabolism.