Open AccessFish oil and wheat germ oil supplementation modulates brain injury in streptozotocin‐induced diabetic rats
Author(s) -
Khedr Naglaa F.
Publication year - 2017
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12518
Subject(s) - glutathione , streptozotocin , malondialdehyde , endocrinology , medicine , superoxide dismutase , oxidative stress , lipid peroxidation , diabetes mellitus , fish oil , antioxidant , chemistry , pharmacology , biochemistry , biology , enzyme , fishery , fish <actinopterygii>
Highlights Uncontrolled hyperglycemia is a risk factor for neurodegenerative sequelae, especially those related to cognitive dysfunction and dementia. Diabetes accelerates inflammation and reactive oxygen species production, and decreases acetylcholine synthesis. In the present study fish oil and wheat germ oil supplementation alleviated oxidative stress and inflammation, and enhanced brain cholinergic function. The mechanisms of neurodegeneration associated with diabetes mellitus include loss of insulin signaling, increased inflammation, and oxidative stress. Adding fish oil and wheat germ oil mix may be a promising adjuvant therapy for preventing neurodegenerative sequelae associated with diabetes.