Open AccessIncreased identification of novel variants in type 2 diabetes, birth weight and their pleiotropic loci
Author(s) -
Zeng ChunPing,
Chen YuanCheng,
Lin Xu,
Greenbaum Jonathan,
Chen YouPing,
Peng Cheng,
Wang XiaFang,
Zhou Rou,
Deng WeiMin,
Shen Jie,
Deng HongWen
Publication year - 2017
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12510
Subject(s) - snp , genome wide association study , single nucleotide polymorphism , birth weight , pleiotropy , type 2 diabetes , false discovery rate , genetics , medicine , genetic association , biology , diabetes mellitus , gene , endocrinology , phenotype , genotype , pregnancy
Highlights This study demonstrates high efficiency of the conditional false discovery rate (c FDR ) method in improving the identification of novel genetic variants of both type 2 diabetes ( T2D ) and birth weight. The findings offer novel insights into potential shared genetic mechanisms in T2D and birth weight, which may form a basis for further biological experiments and clinical replication. The study identified two novel pleiotropic loci that may be related to the processes that affect T2D metabolism and may therefore contribute to the genetic susceptibility to T2D .