Open AccessPeroxisome proliferator‐activated receptor α ligands and modulators from dietary compounds: T ypes, screening methods and functions
Author(s) -
Yang Haixia,
Xiao Lei,
Wang Nanping
Publication year - 2017
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12506
Subject(s) - medicine , peroxisome proliferator activated receptor , peroxisome , receptor , pharmacology , diabetes mellitus , peroxisome proliferator , biochemistry , endocrinology , chemistry
Peroxisome proliferator‐activated receptor α ( PPAR α) plays a key role in lipid metabolism and glucose homeostasis and a crucial role in the prevention and treatment of metabolic diseases. Natural dietary compounds, including nutrients and phytochemicals, are PPAR α ligands or modulators. High‐throughput screening assays have been developed to screen for PPAR α ligands and modulators in our diet. In the present review, we discuss recent advances in our knowledge of PPAR α, including its structure, function, and ligand and modulator screening assays, and summarize the different types of dietary PPAR α ligands and modulators.