Open AccessDocosapentaenoic acid and docosahexaenoic acid are positively associated with insulin sensitivity in rats fed high‐fat and high‐fructose diets
Author(s) -
Huang JiungPang,
Cheng MeiLing,
Hung ChengYu,
Wang ChaoHung,
Hsieh PoShiuan,
Shiao MingShi,
Chen JanKan,
Li DaiEr,
Hung LiMan
Publication year - 2017
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12505
Subject(s) - medicine , endocrinology , docosahexaenoic acid , docosapentaenoic acid , hyperinsulinemia , insulin resistance , insulin , metabolic syndrome , fructose , linoleic acid , lipotoxicity , hyperinsulinism , arachidonic acid , fatty acid , chemistry , polyunsaturated fatty acid , diabetes mellitus , biochemistry , enzyme
Highlights The results indicate that feeding of high‐fat ( HFD ) and high‐fructose diets ( HFrD ) to rats leads to the development of obesity‐ and non‐obesity‐related insulin resistance ( IR ) syndromes, respectively. Docosapentaenoic acid and docosahexaenoic acid are strongly associated with insulin sensitivity. Thus, the findings of the present study provide a potential therapeutic target for IR and metabolic syndrome. In addition, the findings add valuable insights into global metabolic changes after HFD and HFrD feeding. To our knowledge, the present study is the first to perform systemic lipidomic analysis in obesity‐ and non‐obesity‐related IR animals.