Open AccessPost‐partum plasma C ‐peptide and ghrelin concentrations are predictive of type 2 diabetes in women with previous gestational diabetes mellitus 曾患妊娠期糖尿病的妇女的产后血浆C‐肽与饥饿素浓度是2型糖尿病的预测因子
Author(s) -
Lappas Martha,
Jinks Debra,
Ugoni Antony,
Louizos Connie C.J.,
Permezel Michael,
Georgiou Harry M.
Publication year - 2015
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12209
Subject(s) - medicine , gestational diabetes , endocrinology , pregnancy , diabetes mellitus , type 2 diabetes , ghrelin , type 2 diabetes mellitus , body mass index , postpartum period , leptin , gestation , hormone , obesity , genetics , biology
Background Women with previous gestational diabetes mellitus (p GDM ) are at increased risk of developing type 2 diabetes later in life. The aim of this study was to determine if circulating levels of metabolic hormones 12 weeks following a GDM pregnancy are associated with an increased risk of type 2 diabetes 8–10 years later. Methods Fasting plasma concentrations of glucose, insulin, C ‐peptide, ghrelin, GIP , GLP ‐1, glucagon, leptin, PAI ‐1, resistin and visfatin were measured in 98 normal glucose tolerant women, 12 weeks following an index GDM pregnancy. Women were assessed every 2 years for up to 10 years for development of overt type 2 diabetes. Results After a median follow‐up period of 8.7 years, 22.5% of women with a p GDM pregnancy developed type 2 diabetes. Significant risk factors for the development of type 2 diabetes were fasting plasma glucose levels >5 mmol/L during pregnancy and at 12 weeks post‐pregnancy. In addition, higher C ‐peptide levels and lower ghrelin levels at 12 weeks post‐pregnancy were also significant risk factors for the development of type 2 diabetes. Conclusions Fasting plasma glucose during pregnancy and post‐partum, and post‐partum C ‐peptide and ghrelin levels were significant risk factors for the development of type 2 diabetes in women with p GDM . This is the first report that identifies C ‐peptide and ghrelin as potential biomarkers for the prediction of type 2 diabetes in women with a history of GDM .