Open AccessNonalcoholic fatty liver disease is associated with significant coronary artery disease in type 2 diabetic patients: A computed tomography angiography study 在2型糖尿病患者中非酒精性脂肪性肝病与严重冠心病有关：一项计算机断层扫描血管造影研究
Author(s) -
Idilman Ilkay S.,
Akata Deniz,
Hazirolan Tuncay,
Doganay Erdogan Beyza,
Aytemir Kudret,
Karcaaltincaba Musturay
Publication year - 2015
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12172
Subject(s) - medicine , nonalcoholic fatty liver disease , coronary artery disease , diabetes mellitus , fatty liver , metabolic syndrome , type 2 diabetes , hounsfield scale , asymptomatic , gastroenterology , radiology , cardiology , disease , obesity , computed tomography , endocrinology
Background To investigate whether nonalcoholic fatty liver disease ( NAFLD ) is associated with coronary artery disease ( CAD ) in type 2 diabetic patients, who underwent coronary computed tomography angiography ( CTA ). Methods Between J une 2007 and M ay 2010, a total of 273 type 2 diabetic patients without known liver disease underwent coronary CTA for chest pain were enrolled. Axial, multiplanar, and Maximum intensity projection ( MIP ) images were used for determining the cardiovascular disease. Liver fat content was measured from unenhanced CT images obtained for calcium scoring. Moderate and severe NAFLD was defined when mean liver attenuation value is ≤40 Hounsfield Unit ( HU ). Results Among 273 patients, 76% of the patients ( n = 207) had CAD ; 48% of them had significant CAD (≥50 stenosis) by coronary CTA . Patients with CAD were older and male gender was predominant. Mean liver attenuation value calculated with CT was 50 ± 12 HU . Mean liver attenuation value was lower in patients with metabolic syndrome compared to patients without metabolic syndrome ( P < 0.001). Moderate and severe NAFLD was observed in 22% of the patients ( n = 59) with a mean attenuation value of 30 HU . After adjustment of age, gender, obesity, hypertension, smoking status and serum low‐density lipoprotein ( LDL ) levels as coronary risk factors, NAFLD was associated with significant CAD ( P = 0.04). Conclusions In conclusion, the results of the present study indicate that NAFLD is associated with significant CAD in type 2 diabetic patients. Assessment of liver attenuation by CT represents noninvasive evaluation for detection of asymptomatic individuals with NAFLD during coronary CT angiography.