Open AccessContribution of CDKAL1 rs7756992 and IGF2BP2 rs4402960 polymorphisms in type 2 diabetes, diabetic complications, obesity risk and hypertension in the T unisian population 在突尼斯人群中， CDKAL1 rs7756992与 IGF2BP2 rs4402960的多态性对2型糖尿病、糖尿病并发症、肥胖风险以及高血压的影响
Author(s) -
Lasram Khaled,
Ben Halim Nizar,
Benrahma Houda,
MedieneBenchekor Sounnia,
Arfa Imen,
Hsouna Sana,
Kefi Rym,
Jamoussi Henda,
Ben Ammar Slim,
Bahri Sonia,
Abid Abdelmajid,
Benhamamouch Soraya,
Barakat Abdelhamid,
Abdelhak Sonia
Publication year - 2015
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12147
Subject(s) - medicine , type 2 diabetes , diabetes mellitus , endocrinology , overweight , diabetic nephropathy , nephropathy , population , obesity , environmental health
Background The insulin‐like growth factor 2 mRNA ‐binding protein 2 ( IGF2BP2 ) and the cyclin‐dependent kinase 5 regulatory subunit‐associated protein 1‐like 1 ( CDKAL1 ) identified through genome‐wide association ( GWA ) studies have been shown to be associated with Type 2 diabetes in various ethnic groups. In this study, we investigated the association of the rs7756992 of CDKAL1 and the rs4402960 of IGF2BP2 with Type 2 diabetes, diabetic complications (nephropathy, retinopathy and cardiovascular disease), obesity and hypertension in a Tunisian population. Methods A case‐control association study including 200 Type 2 diabetes T unisian patients ( W orld H ealth O rganization criteria) and 208 controls (age ≥40; fasting plasma glucose <6.1 mmol/L; without first degree family history of diabetes) has been performed. Other parameters such as diabetic nephropathy, diabetic retinopathy, cardiovascular disease, overweight/obesity and hypertension have been also collected. Genotyping was performed using TaqMan technology. Results A significant association between the rs4402960 and Type 2 diabetes ( OR = 1.86, 95% CI = 1.34–2.58, P < 10 −4 ) has been found. Overweight/obese subjects bearing the T‐allele have an increased risk to develop Type 2 diabetes ( OR = 2.06, 95% CI = 1.40–3.03, P < 10 −4 ). Furthermore, the rs7756992 was found to be associated with the reduced risk of diabetic nephropathy in patients with diabetes ( OR = 0.44, 95% CI = 0.27–0.73, P = 0.001). Conclusions The present study confirms that the rs4402960 of IGF2BP2 gene is a strong candidate for Type 2 diabetes susceptibility and overweight/obesity risk in the T unisian population. Interestingly, our data suggest that the rs7756992 of CDKAL1 gene have a protective effect against diabetic nephropathy.