Relationship between platelet volume indices with macrovascular and peripheral neuropathy complications in type 2 diabetic patients (2型糖尿病患者血小板容积参数与大血管及外周神经并发症的相关性研究)

Background The relationship of platelet volume indices including mean platelet volume ( MPV ) and platelet distribution width ( PDW ) with carotid intima‐media thickness ( IMT ) as well as vibration perception threshold ( VPT ) was investigated in type 2 diabetic patients. Methods A total of 500 type 2 diabetic patients (298 male, 202 female) were enrolled. Clinical and laboratory data were collected from hospital records. Results Both MPV and PDW were significantly associated with carotid IMT , after adjustment for confounding factors including age, systolic blood pressure, total cholesterol and creatinine (0.833 ± 0.029 mm vs 0.955 ± 0.030 mm; 0.839 ± 0.029 mm vs 0.955 ± 0.030 mm; P  = 0.0015 and P  = 0.022, respectively). Agreed with carotid IMT analysis results, significant association was found between PDW and VPT as tertiles (15.760 ± 1.091V vs 20.187 ± 1.094V, P  = 0.016). In multivariable analysis, both MPV and PDW were significantly associated with VPT ( P  = 0.021 and P  = 0.007, respectively). However, only PDW , but not MPV , was significantly associated with carotid IMT ( P  = 0.002). Conclusions These findings implied the predictive value of platelets volume indices in vascular and peripheral neuropathy complications in type 2 diabetes.