Open AccessElevated serum uric acid levels are independent risk factors for diabetic foot ulcer in female C hinese patients with type 2 diabetes (血尿酸水平升高是中国女性2型糖尿病患者糖尿病足溃疡的独立危险因素)
Author(s) -
Ye Xiao,
Cao Ying,
Gao Fang,
Yang Qunying,
Zhang Qian,
Fu Xiajun,
Li Jimin,
Xue Yaoming
Publication year - 2014
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12079
Subject(s) - medicine , uric acid , odds ratio , gastroenterology , diabetes mellitus , type 2 diabetes , confidence interval , diabetic foot , diabetic foot ulcer , confounding , hyperuricemia , logistic regression , univariate analysis , risk factor , endocrinology , multivariate analysis
Background To investigate the relationship between elevated serum uric acid levels and the presence of diabetic foot ulcer ( DFU ) in C hinese patients with type 2 diabetes ( T2D ). Methods A retrospective study was performed on 829 outpatients with T2D (478 men, 351 women) who visited the Diabetes Clinic ( N anfang H ospital, S outhern M edical U niversity) from J anuary 2007 to D ecember 2009. Information regarding their clinical history, anthropometric measurements, and laboratory data were collected. Potential confounding variables with P < 0.10 were adjusted for in multivariate logistic regression analysis. Results In univariate analyses, there was a significant difference in serum uric acid levels between female patients with and without DFU (370 ± 128 vs. 313 ± 107 μmol/L, respectively; P < 0.05), but not between male patients with and without DFU (317 ± 100 vs. 348 ± 111 μmol/L, respectively; P = 0.643). The prevalence of DFU among quintiles of uric acid levels (from 1–20% to 80–100%) was 5.3%, 3.9%, 7.7%, 5.5%, and 16.7%, respectively. Using uric acid level as a continuous variable, the multivariate‐adjusted odds ratio for diabetic foot ulcer in female patients was 1.004 (95% confidence interval 1.001–1.008; P < 0.05). Conclusions Elevated uric acid levels are a significant and independent risk factor for diabetic foot ulcer in female C hinese patients with T2D . Whether serum uric acid is involved in the pathogenesis of DFU in female patients remains to be investigated.