Open AccessDiabetes and cancer relationships (糖尿病与肿瘤的关联性)
Author(s) -
Wang Tiange,
Ning Guang,
Bloomgarden Zachary
Publication year - 2013
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12057
Subject(s) - medicine , diabetes mellitus , malignancy , cancer , incidence (geometry) , insulin , type 2 diabetes , bioinformatics , clinical trial , intensive care medicine , oncology , endocrinology , biology , physics , optics
Diabetes and cancer are both heterogeneous and multifactorial diseases with tremendous impact on health worldwide. Epidemiologic evidence suggests that certain malignancies may be associated with diabetes, as well as with diabetes risk factors and, perhaps, with certain diabetes treatments. Numerous biological mechanisms could account for these relationships. Insulin‐like growth factor ( IGF )‐1, IGF ‐2, IGF ‐1 receptors, insulin, and the insulin receptor play roles in the development and progression of cancers. Although evidence from randomized controlled trials does not support or refute associations of diabetes and its treatments with either increased or reduced risk of cancer incidence or prognosis, consideration of malignancy incidence rates and the magnitude of the trials that would be required to address these issues explains why such studies may not be readily undertaken.