Gastric emptying of solids and its relationship with microalbuminuria in children and adolescents with type 1 diabetes mellitus (儿童与青少年1型糖尿病患者的固体食物胃排空情况以及它与微量白蛋白尿之间的关系)

Background The aims of the present study were to determine the frequency of delayed gastric emptying in children and adolescents with type 1 diabetes mellitus ( T1DM ) and to investigate the relationship between gastric emptying rate and other contributing factors (e.g. serum HbA1c , duration of diabetes and microalbuminuria) in these patients. Methods This was a clinical trial evaluating the rate of gastric emptying of solid meals in 33 children and adolescents with T1DM and in 26 healthy peers using a radionuclide method. Three consecutive overnight urine collections were used to calculate the albumin excretion rate. Results There was no significant difference in the gastric half‐emptying time ( GE t ½ ) between patients and controls (151.7 ± 154.5 vs 109.8 ± 60.5 min, respectively; P  = 0.885) or the frequency of delayed gastric emptying (36.4% vs 30.8%, respectively; P  = 0.433). There was a moderately positive correlation between GE t ½ and the duration of diabetes ( r  = 0.380; P  = 0.029). There was no correlation between GE t ½ and microalbumin levels in T1DM patients. In these patients, the body mass index standard deviation scores were significantly lower than in patients with normal gastric emptying (–0.13 ± 0.87 vs 0.7 ± 1.23, respectively; P  = 0.044). Conclusion Progression of delayed gastric emptying is more likely to be related to a longer duration of diabetes than glycemic control in children and adolescents with T1DM . Patients with delayed gastric emptying are thinner compared with patients with a normal rate of gastric emptying; they may also be asymptomatic.