Open AccessAssociation between glucose transporter 1 rs841853 polymorphism and type 2 diabetes mellitus risk may be population specific (葡萄糖转移酶1的rs841853基因多态性与2型糖尿发生风险的关系可能具有人群特异性)
Author(s) -
Du Bing,
Liu Shengmao,
Cui Chengji,
Wang Songyan,
Cui Wenpeng
Publication year - 2013
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12042
Subject(s) - odds ratio , meta analysis , medicine , allele , type 2 diabetes mellitus , subgroup analysis , publication bias , genetic model , confidence interval , type 2 diabetes , population , polymorphism (computer science) , genetic association , diabetes mellitus , genetics , genotype , endocrinology , biology , single nucleotide polymorphism , gene , environmental health
Background So far, studies on the association between the glucose transporter 1 ( GLUT1 ) rs841853 polymorphism and type 2 diabetes mellitus ( T2DM ) risk have generated considerable controversy. The present study was performed to clarify the association of this genetic variation with T2DM . Methods A comprehensive literature search of electronic databases was conducted to obtain articles focused on the relationship between the GLUT1 rs841853 polymorphism and T2DM , followed by a systemic meta‐analysis. Results Fourteen articles and 19 individual studies were included for analysis. Main analyses revealed extreme heterogeneity and random effect pooled odds ratios ( OR ) were weakly significant in allele contrast ( OR 1.28; 95% confidence interval [ CI ] 1.01, 1.63; P = 0.04) and dominant model ( OR 1.52; 95% CI 1.19, 1.94; P = 0.0008) for T allele. Subgroup analyses for C aucasians showed marginal positive results in the dominant model. However, analyses for A sians yielded an obvious relationship to T2DM risk in all genetic models. Interestingly, T allele even seemed to be a protective factor against the development of T2DM in Blacks in allele contrast. Sensitivity analyses did not alter materially for most comparisons and no publication bias was found in this meta‐analysis. Conclusions The results of the present meta‐analysis provide evidence that the GLUT1 rs841853 polymorphism may confer increased susceptibility to T2DM in A sians. However, there is no currently available strong evidence supporting the association between this genetic variation and T2DM in C aucasians, B lacks, or the overall population.