Open AccessVitamin D and Type 2 diabetes mellitus (维生素D与2型糖尿病)
Author(s) -
Xuan Yan,
Zhao Hongyan,
Liu JianMin
Publication year - 2013
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12024
Subject(s) - medicine , insulin resistance , vitamin d and neurology , endocrinology , diabetes mellitus , type 2 diabetes mellitus , vitamin d deficiency , type 2 diabetes , calcitriol receptor , vitamin , insulin , pathogenesis , inflammation
Based on increasing evidence from animal and human studies, vitamin D deficiency is now regarded as a potential risk factor for Type 2 diabetes mellitus ( T2DM ). Vitamin D is involved in the pathogenesis of pancreatic β ‐cell dysfunction, insulin resistance, and systemic inflammation, conditions that contribute to the development of T2DM . Vitamin D can affect the progress of this disease directly through the activation of its own receptor, and indirectly via the regulation of calcium homeostasis. Observational studies have revealed the association between vitamin D deficiency and incident T2DM . More double‐blind randomized control studies that investigate the effects of vitamin D supplementation on insulin sensitivity, insulin secretion, and the occurrence of T2DM are needed.