Open AccessA structurally unique Fusobacterium nucleatum tannase provides detoxicant activity against gallotannins and pathogen resistance
Author(s) -
Mancheño José Miguel,
Atondo Estíbaliz,
TomásCortázar Julen,
Luís Lavín José,
PlazaVinuesa Laura,
MartínRuiz Itziar,
Barriales Diego,
Palacios Ainhoa,
Daniel Navo Claudio,
Sampedro Leticia,
PeñaCearra Ainize,
Ángel PascualItoiz Miguel,
Castelo Janire,
CarrerasGonzález Ana,
Castellana Donatello,
Pellón Aize,
Delgado Susana,
RuasMadiedo Patricia,
las Rivas Blanca,
Abecia Leticia,
Muñoz Rosario,
JiménezOsés Gonzalo,
Anguita Juan,
Rodríguez Héctor
Publication year - 2022
Publication title -
microbial biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.287
H-Index - 74
ISSN - 1751-7915
DOI - 10.1111/1751-7915.13732
Subject(s) - fusobacterium nucleatum , tannase , spermidine , chemistry , acetylation , biochemistry , microbiology and biotechnology , lactobacillus plantarum , bacteria , biology , enzyme , lactic acid , gallic acid , gene , genetics , porphyromonas gingivalis , antioxidant
A new tannase enzyme from the cancer‐related pathogen Fusobacterium nucleatum is important for the survival of the bacteria under the stress conditions derived from the presence of dietary gallotannins. Using structural studies and molecular modelling we describe new structural features for this enzyme. The inhibition of the enzyme by spermidine and its acetylated derivatives conduce to higher susceptibility to diet phenolic gallotannins and decreased fitness of F. nucleatum .