Open AccessDiallyl sulfide from garlic suppresses quorum‐sensing systems of Pseudomonas aeruginosa and enhances biosynthesis of three B vitamins through its thioether group
Author(s) -
Li WenRu,
Zeng TaoHua,
Yao JunWei,
Zhu LiPing,
Zhang ZhiQing,
Xie XiaoBao,
Shi QingShan
Publication year - 2021
Publication title -
microbial biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.287
H-Index - 74
ISSN - 1751-7915
DOI - 10.1111/1751-7915.13729
Subject(s) - pyocyanin , quorum sensing , pseudomonas aeruginosa , diallyl disulfide , virulence , biosynthesis , rhamnolipid , biochemistry , microbiology and biotechnology , biofilm , chemistry , transcription (linguistics) , biology , gene , bacteria , genetics , apoptosis , linguistics , philosophy
Diallyl disulfide (DAS) from garlic did not affect the growth dynamics of Pseudomonas aeruginosa PAO1; however, DAS inhibited transcription of most of the quorum sensing (QS) system genes, including lasR, rhlI/rhlR, and pqsABCDE/pqsR; thus, biosynthesis of the signal molecules C4‐HSL (encoded by rhlI) and PQS (encoded by pqsABCDE) was inhibited.DAS suppressed the production of some virulence factors toxic to the host and enhanced the production of some nutrition factors beneficial to the host. These actions of DAS may be due to its thioether group.