Open AccessPhage cocktail strategies for the suppression of a pathogen in a cross‐feeding coculture
Author(s) -
Fazzino Lisa,
Anisman Jeremy,
Chacón Jeremy M.,
Harcombe William R.
Publication year - 2020
Publication title -
microbial biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.287
H-Index - 74
ISSN - 1751-7915
DOI - 10.1111/1751-7915.13650
Subject(s) - lytic cycle , bacteriophage , biology , pathogen , escherichia coli , microbiology and biotechnology , bacteria , salmonella enterica , human pathogen , genetics , gene , virus
Predicting which combinations (cocktails) of bacteria‐infecting viruses (bacteriophage) will suppress pathogenic bacterial growth is complicated, in part, due to the complex ecological interactions of host bacteria, but important for effective treatment. We found that when hosts cross‐feed (exchange nutrients) with nonhost bacterial species, cocktails that include a bacteriophage infecting the nonhost cross‐feeding partner can be more effective at suppressing pathogenic bacteria than targeting the pathogenic bacterium with multiple bacteriophage species. This is a novel cocktail formulation.