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We demonstrated the capacity of  Aspergillus nidulans  to degrade HMF and related compounds and analysed the genetic basis of the degradation pathway. Gene deletion mutants confirmed that AN7164 encodes a furan‐2,5‐dicarboxylic acid decarboxylase in this fungus. The AN7164 orthogroup is not found widespread across distinct fungal classes, contrary to the AN4212 orthogroup (responsible for the direct transformation of HMF) that is widespread and highly redundant.

microbial biotechnology

Securing a furan‐based biorefinery: disclosing the genetic basis of the degradation of hydroxymethylfurfural and its derivatives in the model fungus  Aspergillus nidulans