Open AccessElectron availability in CO 2 , CO and H 2 mixtures constrains flux distribution, energy management and product formation in Clostridium ljungdahlii
Author(s) -
Hermann Maria,
Teleki Attila,
Weitz Sandra,
Niess Alexander,
Freund Andreas,
Bengelsdorf Frank R.,
Takors Ralf
Publication year - 2020
Publication title -
microbial biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.287
H-Index - 74
ISSN - 1751-7915
DOI - 10.1111/1751-7915.13625
Subject(s) - chemistry , carbon monoxide dehydrogenase , ferredoxin , flux (metallurgy) , syngas , metabolic flux analysis , carbon monoxide , metabolic engineering , nad+ kinase , biochemistry , metabolism , organic chemistry , enzyme , catalysis
Our studies compared the impact of the gas mixtures CO 2 + H 2 , syngas and CO on the intracellular flux distribution, energy management, product formation and electron efficiency of C. ljungdahlii . The advantage of CO consumption for producing reduced products such as alcohols is pinpointed. In addition, we demonstrated that the Wood‐Ljungdahl pathway adapts its main function depending on the gas mixture consumed.