Open AccessProtective effects of bifidobacteria against enteropathogens
Author(s) -
Aw Wanping,
Fukuda Shinji
Publication year - 2019
Publication title -
microbial biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.287
H-Index - 74
ISSN - 1751-7915
DOI - 10.1111/1751-7915.13460
Subject(s) - metabolome , metagenomics , metabolomics , microbiome , biology , computational biology , probiotic , host (biology) , bacteria , bioinformatics , ecology , genetics , gene
Summary Recent major advances in metagenomics and metabolomics technologies have enabled us to collect more data on the gut microbiome and metabolome to evaluate its influence on host health. In this short opinion article, we have chosen to focus on summarizing the protective mechanisms of bifidobacteria, a highly regarded probiotic, and it's metabolite: acetate; against enteropathogens, specifically in the E. coli O157:H7 mice model. We advocate for using a novel approach metabologenomics, which is an integration of metagenomic and metabolomic information on a systems biology‐wide approach to better understand this interplay between gut microbiome and host metabolism.