Synthetic consortia of nanobody‐coupled and formatted bacteria for prophylaxis and therapy interventions targeting microbiome dysbiosis‐associated diseases and co‐morbidities | Zendy

Timmis Kenneth | Zendy; Timmis James Kenneth | Zendy; Brüssow Harald | Zendy; Fernández Luis Ángel | Zendy

Open Access

Synthetic consortia of nanobody‐coupled and formatted bacteria for prophylaxis and therapy interventions targeting microbiome dysbiosis‐associated diseases and co‐morbidities

Author(s) -

Timmis Kenneth,

Timmis James Kenneth,

Brüssow Harald,

Fernández Luis Ángel

Publication year - 2019

Publication title -

microbial biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.287

H-Index - 74

ISSN - 1751-7915

DOI - 10.1111/1751-7915.13355

Subject(s) - dysbiosis , microbiome , bacteria , medicine , psychological intervention , microbiology and biotechnology , immunology , biology , computational biology , intensive care medicine , bioinformatics , genetics , psychiatry

Designed nanobody‐linked synthetic consortia for microbiota dysbiosis therapies. A. Nanobodies (Nb) are selected for specific antigens on target bacteria destined for a synthetic therapy consortium that may consist of two (B) or multiple (C) members. For the treatment of dysbiosis co‐morbidities requiring two functionally distinct consortia, these may be linked through a common member to generate a single bi‐functional microbiota therapy (D).

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