Open AccessAntibiotic drug discovery
Author(s) -
Wohlleben Wolfgang,
Mast Yvonne,
Stegmann Evi,
Ziemert Nadine
Publication year - 2016
Publication title -
microbial biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.287
H-Index - 74
ISSN - 1751-7915
DOI - 10.1111/1751-7915.12388
Subject(s) - drug discovery , antibiotics , drug development , drug , medicine , biology , intensive care medicine , bioinformatics , pharmacology , microbiology and biotechnology
Summary Due to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in the last 20 years, the approval for new antibacterial agents had decreased. The field of natural product discovery has undergone a tremendous development over the past few years. This has been the consequence of several new and revolutionizing drug discovery and development techniques, which is initiating a ‘New Age of Antibiotic Discovery’. In this review, we concentrate on the most significant discovery approaches during the last and present years and comment on the challenges facing the community in the coming years.