Initiation of the flexirubin biosynthesis in   C   hitinophaga pinensis | Zendy

Schöner Tim A. | Zendy; Fuchs Sebastian W. | Zendy; Schönau Christian | Zendy; Bode Helge B. | Zendy

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Initiation of the flexirubin biosynthesis in C hitinophaga pinensis

Author(s) -

Schöner Tim A.,

Fuchs Sebastian W.,

Schönau Christian,

Bode Helge B.

Publication year - 2014

Publication title -

microbial biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.287

H-Index - 74

ISSN - 1751-7915

DOI - 10.1111/1751-7915.12110

Subject(s) - biosynthesis , biochemistry , gene cluster , polyene , chemistry , bacteria , thioester , tandem mass spectrometry , pigment , mass spectrometry , biology , gene , chromatography , organic chemistry , enzyme , genetics

Summary Bacteria from the Bacteroidetes phylum are known producers of the chemotaxonomic relevant flexirubins. These orange pigments comprise a non‐isoprenoid aryl‐polyene carboxylic acid esterified with a dialkylresorcinol. Herein, we report a gene cluster from C hitinophaga pinensis encoding the biosynthesis of the polyene moiety and the biochemical characterization of a tyrosine ammonia‐lyase and a 4‐coumarate‐ CoA ligase responsible for the initiation of the polyene biosynthesis. Additionally, the flexirubin of C . pinensis was characterized by a combination of feeding experiments, high‐performance liquid chromatography tandem mass spectrometry and matrix‐assisted laser desorption/ionization mass spectrometry.

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