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Serum syndecan‐4 is associated with nonalcoholic fatty liver disease
Author(s) -
Xia Shu Jing,
Tang Li Zhong,
Li Wen Hua,
Xu Zhao Shan,
Zhang Li Li,
Cheng Feng Gan,
Chen Hong Xia,
Wang Zi Hua,
Luo Yu Cheng,
Dai An Na,
Fan Jian Gao
Publication year - 2021
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.13037
Subject(s) - medicine , insulin resistance , nonalcoholic fatty liver disease , odds ratio , confidence interval , receiver operating characteristic , gastroenterology , homeostatic model assessment , fatty liver , metabolic syndrome , obesity , disease
Objectives The accelerated shedding of extracellular domains of syndecan‐4 (SDC4) is associated with central obesity and insulin resistance, while the association between serum SDC4 and nonalcoholic fatty liver disease (NAFLD) is unknown. We aimed to examine the association between SDC4 and NAFLD. Methods Adults undergoing a health examination from 1 June 2019 to 31 December 2019 were enrolled. A diagnosis of NAFLD was made with an abdominal ultrasound. Logistic regression models and the receiver operating characteristic (ROC) curves were used to evaluate the role of SDC4 in predicting NAFLD. Results In total, 533 eligible participants were finally enrolled, among them 157 (29.46%) had NAFLD. The proportion of patients with NAFLD increased with the increasing quartiles of serum SDC4. With the increase of serum SDC4 levels, metabolic features including waist circumference, serum triglyceride, total cholesterol, fasting blood glucose, fasting insulin and homeostasis model assessment of insulin resistance were significantly increased. SDC4 was an independent factor for NAFLD (odds ratio 1.963, 95% confidence interval [CI] 1.628‐2.367, P < 0.001). The area under the ROC curve of SDC4 for predicting NAFLD was 0.934 (95% CI 0.910‐0.959). The optimal cut‐off value was 6.575 ng/mL at Youden's index of 0.767. SDC4 had the highest diagnostic sensitivity (84.1%), positive predictive value (82.5%), negative predictive value (93.3%) and positive likelihood ratio (11.356) among all the variables. Conclusions Elevated serum SDC4 level is associated with metabolic disorders and the prevalence of NAFLD among general population. Serum SDC4 may serve as a biomarker of NAFLD.