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Efficacy and safety of drugs for nonalcoholic steatohepatitis
Author(s) -
Shen Bo,
Lu Lun Gen
Publication year - 2021
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12967
Subject(s) - medicine , obeticholic acid , pioglitazone , nonalcoholic steatohepatitis , cirrhosis , steatohepatitis , clinical trial , type 2 diabetes , nonalcoholic fatty liver disease , type 2 diabetes mellitus , gastroenterology , fatty liver , diabetes mellitus , pharmacology , disease , endocrinology , agonist , receptor
Nonalcoholic steatohepatitis (NASH) is an inflammatory type of nonalcoholic fatty liver disease and is associated with the development and progression of cirrhosis. Lifestyle intervention is still the predominant treatment for NASH. So far, no drugs have been approved to treat NASH by the U.S. Food and Drug Administration (FDA). Vitamin E has been recommended for patients with NASH without type 2 diabetes mellitus (T2DM), whereas a combination of pioglitazone and vitamin E is recommended for patients with both NASH and T2DM. Encouragingly, drugs are currently being developed for different NASH mechanisms. Some of the drugs are at phase III clinical trials, including obeticholic acid (OCA), Elafibranor, Cenicriviroc, Selonsertib, Resmetirom, Emricasan and Aramchol. Due to its positive interim effect in attenuating the degree of hepatic fibrosis OCA was filing in FDA. However, it has been rejected by the U.S FDA and has been advised to conduct long‐term studies. Therefore, in this article, we reviewed the efficacy and safety of drugs currently under clinical trials for NASH.