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Role of NLRP3 inflammasome in liver disease
Author(s) -
Al Mamun Abdullah,
Akter Afroza,
Hossain Sukria,
Sarker Tamanna,
Safa Shoronika A.,
Mustafa Quazi G.,
Muhammad Syed A.,
Munir Fahad
Publication year - 2020
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12918
Subject(s) - inflammasome , medicine , steatohepatitis , immunology , pathogenesis , disease , fatty liver , liver injury , innate immune system , nod , inflammation , cancer research , immune system , pathology , diabetes mellitus , endocrinology
Inflammasomes have become an important natural sensor of host immunity, and can protect various organs against pathogenic infections, metabolic syndromes, cellular stress and cancer metastasis. Inflammasomes are intracellular multi‐protein complexes found in both parenchymal and non‐parenchymal cells, stimulating the initiation of caspase‐1 and interleukin (IL)‐1β and IL‐18 in response to cell danger signals. Inflammasomes induce cell death mechanisms. The potential role of NOD‐like receptor protein 3 (NLRP3) inflammasome in alcoholic and non‐alcoholic steatohepatitis, hepatitis, nanoparticle‐induced liver injury and other liver diseases has recently attracted widespread attention from clinicians and researchers. In this review we summarize the role played by the NLRP3 inflammasome in molecular and pathophysiological mechanisms in the pathogenesis and progression of liver disease. This article aims to establish that targeting the NLRP3 inflammasome and other inflammasome components may make a significant therapeutic approach to the treatment of liver disease.