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Preventing esophageal strictures with steroids after endoscopic submucosal dissection in superficial esophageal neoplasm
Author(s) -
Pih Gyu Young,
Kim Do Hoon,
Gong Eun Jeong,
Na Hee Kyong,
Jung Kee Wook,
Lee Jeong Hoon,
Ahn Ji Yong,
Choi Kee Don,
Song Ho June,
Lee Gin Hyug,
Jung HwoonYong
Publication year - 2019
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12819
Subject(s) - medicine , esophageal stricture , endoscopic submucosal dissection , odds ratio , confidence interval , gastroenterology , risk factor , univariate analysis , surgery , topical steroid , multivariate analysis , esophagus
Objectives This study aimed to investigate the efficacy of prophylactic steroid administration in preventing post‐endoscopic submucosal dissection (ESD) esophageal stricture and to determine risk factors for these strictures. Methods Patients who underwent ESD for superficial esophageal neoplasms with a mucosal defect affecting >75% of the esophageal circumference between January 2011 and August 2016 were eligible. Patients were classified into three groups, including ESD‐alone group (n = 22), oral steroid group (n = 25) and intralesional steroid injection group (n = 6). Univariate and multivariate logistic regression analyses were performed to evaluate the risk factors for esophageal stricture. Results The stricture rate was 50.0%, 20.0% and 33.3% in the ESD‐alone group, oral steroid group and steroid injection group, respectively. Patients treated with steroids had a significantly lower stricture rate than the ESD‐alone group (22.6% vs 50.0%, P = 0.046). Additionally, oral steroid group had a significantly lower stricture rate than the ESD‐alone group ( P = 0.037). Multivariate analysis revealed that the extent of the circumferential mucosal defect was a significant risk factor for post‐ESD strictures (odds ratio [OR] 13.015, 95% confidence interval [CI] 2.257‐76.077, P = 0.004). The administration of steroids (OR 0.108, 95% CI 0.020‐0.578, P = 0.009), specifically oral steroids (OR 0.109, 95% CI 0.019‐0.622, P = 0.013), was associated with prevention of post‐ESD strictures. Conclusion Oral steroid prophylaxis appears to be a safe and effective treatment in preventing post‐ESD stricture and improving patients' quality of life.