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Special clinical characteristics and outcomes in Chinese pediatric patients with early‐onset Crohn's disease
Author(s) -
Tang Wen Juan,
Shi Peng,
Zheng Cui Fang,
Shi Jie Ru,
Qiu Xiao Xia,
Wang Sheng Nan,
Huang Ying
Publication year - 2019
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12803
Subject(s) - medicine , gastroenterology , crohn's disease , hematochezia , anemia , diarrhea , disease , pediatrics , colonoscopy , cancer , colorectal cancer
Objective To study the clinical and nutritional characteristics of early‐onset Crohn's disease (EO‐CD) in China. Methods Patients were defined as having EO‐CD (age at diagnosis <10 y) or late‐onset Crohn's disease (LO‐CD; age at diagnosis of 10‐17 y). Their characteristics, clinical, and nutritional data were collected at baseline and at each follow‐up visit. Statistical analyses were used to compare differences in both groups. Results From July 1993 to February 2017, of the 137 children enrolled, 68 (49.6%) had EO‐CD and 69 (50.4%) had LO‐CD. More patients with EO‐CD than those with LO‐CD presented with diarrhea, hematochezia, growth delay, anemia and skin disease, and had higher pediatric Crohn's disease activity index scores at diagnosis (all P < 0.05). Fewer patients with EO‐CD achieved their first remission (42.6% vs 76.8%, P < 0.0001) during follow‐up. Patients with EO‐CD required a longer treatment time to reach remission ( P = 0.0049) and had a higher mortality rate ( P = 0.0133), as well as lower height and weight percentiles ( P = 0.0200 and 0.0288, respectively), hemoglobin ( P = 0.0185) and albumin levels ( P = 0.0002), zinc ( P = 0.0024) and iron ( P = 0.0110) concentrations in blood at diagnosis. Conclusion The EO‐CD group had worse clinical outcomes and nutritional status than the LO‐CD group.