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Influence of serum vitamin D level on Helicobacter pylori eradication: A multi‐center, observational, prospective and cohort study
Author(s) -
Han Chuan,
Ni Zhen,
Yuan Ting,
Zhang Jian,
Wang Chan,
Wang Xin,
Ning Han Bing,
Liu Jie,
Sun Nina,
Liu Cai Fang,
Shi Miao,
Lu Wen Quan,
Shi Yong Quan
Publication year - 2019
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12793
Subject(s) - medicine , helicobacter pylori , gastroenterology , odds ratio , prospective cohort study , confidence interval , urea breath test , vitamin d and neurology , vitamin , helicobacter pylori infection
Objectives This study was designed to test whether serum vitamin D levels affected Helicobacter pylori ( H. pylori ) infection and eradication rates. Methods A multicenter observational prospective cohort study was conducted. A total of 496 H. pylori − positive ( H. pylori + ) and 257 H. pylori ‐negative ( H. pylori − ) patients were enrolled from four hospitals in China. Baseline serum vitamin D levels were measured and a 13 C‐urea breath test (UBT) was performed for all the participants. The H. pylori + patients were divided into two subgroups based on their serum vitamin D levels (<10 or ≥10 ng/mL). A second 13 C‐UBT was performed between 4 and 8 weeks after 14‐day bismuth‐containing quadruple eradication therapies. Factors potentially affecting H. pylori eradication were determined using a questionnaire survey. Results Serum vitamin D levels were significantly lower in the H. pylori + group than in the H. pylori − group ([17.0 ± 6.9] ng/mL vs [19.2 ± 8.0] ng/mL, P = 0.000). H. pylori eradication rate significantly differed between patients with serum vitamin D levels of <10 ng/mL and ≥10 ng/mL (71.7% vs 87.3%, P = 0.005). A multivariate analysis showed that having serum vitamin D level ≥10 ng/mL was an independent risk factor for a successful H. pylori eradication (odds ratio 0.381, 95% confidence interval 0.183‐0.791, P = 0.010). Conclusions Serum vitamin D level may affect H. pylori infection and its eradication. Randomized controlled trials are needed to find out whether vitamin D supplements may increase the H. pylori eradication rate.