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Precision medicine for autoimmune hepatitis
Author(s) -
Chen Rui Ling,
Wang Qi Xia,
Ma Xiong
Publication year - 2019
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12786
Subject(s) - autoimmune hepatitis , medicine , precision medicine , pharmacogenomics , hypergammaglobulinemia , autoantibody , hepatitis , disease , immunology , personalized medicine , bioinformatics , pathology , pharmacology , antibody , biology
Autoimmune hepatitis (AIH) is an autoimmune liver disease induced by environmental factors in genetically susceptible individuals. AIH is characterized by hypergammaglobulinemia, elevation of serum autoantibodies and transaminases, and interface hepatitis. Personalized therapy is necessary in AIH because of its heterogeneity in clinical manifestations. Precision medicine is a recent and novel therapeutic pattern which ultimately aims to achieve personalized therapy. In this review we summarize the research progress of precision medicine to treat AIH by an exploration of the susceptible genes, precision diagnosis and prognosis of AIH, pharmacogenomics and precision medication, and the precision treatment for special types of AIH.