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Circulating miR‐29b positively correlates with non‐alcoholic fatty liver disease in a Chinese population
Author(s) -
He Zhen,
Yang Jian Jun,
Zhang Rong,
Li Hua Ting,
Wu Liang,
Jiang Feng,
Jia Wei Ping,
Hu Cheng
Publication year - 2019
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12716
Subject(s) - fatty liver , medicine , triglyceride , body mass index , odds ratio , type 2 diabetes , gastroenterology , type 2 diabetes mellitus , population , endocrinology , diabetes mellitus , disease , cholesterol , environmental health
Objective Early screening of non‐alcoholic fatty liver disease (NAFLD) is of great significance for the early detection and intervention in NAFLD. MicroRNAs (miRNAs) are important regulators of metabolic diseases including NAFLD. The aim of this study was to investigate the association of serum miR‐29a‐c with NAFLD in a Chinese population. Methods Participants were divided into four groups based on the presence or absence of NAFLD and/or type 2 diabetes mellitus (T2DM). Quantitative polymerase chain reaction analysis was performed to quantify serum level of miR‐29a‐c. The association of miR‐29a‐c with NAFLD was evaluated. Results Serum miR‐29b, but not miR‐29a or miR‐29c, was positively associated with NAFLD (odds ratio [OR] 2.04 [1.16‐ 3.58], P = 0.013). Additionally, age, serum triglyceride and fasting plasma glucose (FPG) levels were independently associated with miR‐29b (β ± standard error [SE] = 0.004 ± 0.002, P = 0.019 for age; β ± SE = 0.110 ± 0.054, P = 0.042 for triglyceride; and β ± SE = 0.389 ± 0.161, P = 0.016 for FPG). MiR‐29b level was positively correlated with intrahepatic lipid content (β ± SE = 6.055 ± 2.630, P = 0.024) after adjusted for age, sex, and body mass index. Conclusions Serum miR‐29b was associated with intrahepatic lipid content and NAFLD in a Chinese population‐based study.