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Role of fecal microbiota transplantation in inflammatory bowel disease
Author(s) -
D'Odorico Irene,
Di Bella Stefano,
Monticelli Jacopo,
Giacobbe Daniele R,
Boldock Emma,
Luzzati Roberto
Publication year - 2018
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12603
Subject(s) - medicine , inflammatory bowel disease , fecal bacteriotherapy , gut flora , disease , transplantation , intensive care medicine , immunology , immune system , pathogenesis , antibiotics , clostridium difficile , biology , microbiology and biotechnology
There is increasing evidence of the key role played by altered intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD). Management strategies involving immune modulation are effective and widely used, but treatment failures and side effects occur. Fecal microbiota transplantation (FMT) provides a novel, perhaps complementary, strategy to restore the normal gut microbiota in patients with IBD. This review summarizes the available efficacy and safety data on the use of FMT in patients with IBD. Several aspects remain to be clarified about the clinical predictors of the response to FMT, its most appropriate route of administration, and the most appropriate quantity and quality of microbiota to be transplanted. Further studies focusing on long‐term outcomes and safety are also warranted.