Premium
Vitamin D administration leads to a shift of the intestinal bacterial composition in Crohn's disease patients, but not in healthy controls
Author(s) -
Schäffler Holger,
Herlemann Daniel PR,
Klinitzke Paul,
Berlin Peggy,
Kreikemeyer Bernd,
Jaster Robert,
Lamprecht Georg
Publication year - 2018
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12591
Subject(s) - crohn's disease , dysbiosis , roseburia , medicine , firmicutes , vitamin d and neurology , inflammatory bowel disease , vitamin , microbiome , gut flora , immunology , gastroenterology , disease , biology , bacteria , bacteroides , 16s ribosomal rna , bioinformatics , genetics
OBJECTIVE Dysbiosis is a common feature in the pathogenesis of inflammatory bowel diseases (IBD). Environmental factors, such as vitamin D deficiency, seem to play a role in the intestinal inflammation of IBD. The aim of this study was to investigate whether vitamin D administration has an impact on the bacterial composition in Crohn's disease (CD) compared to healthy controls (HC). METHODS A prospective, longitudinal, controlled interventional analysis was conducted in seven patients with CD in clinical remission and 10 HC to investigate the effect of orally administrated vitamin D on the intestinal bacterial composition using 16S ribosomal RNA gene amplicon sequencing. Clinical parameters were assessed. RESULTS In contrast to HC, microbial communities of CD patients changed significantly during early vitamin D administration. However, a further increase in vitamin D level was associated with a reversal of this effect and additionally with a decrease in the bacterial richness in the CD microbiome. Specific species with a high abundancy were found during vitamin D administration in CD, but not in HC; the abundancy of Alistipes , Barnesiella , unclassified Porphyromonadaceae (both Actinobacteria), Roseburia, Anaerotruncus , Subdoligranulum and an unclassified Ruminococaceae (all Firmicutes) increased significantly after 1‐week vitamin D administration in CD. CONCLUSIONS Vitamin D has a specific influence on the bacterial communities in CD, but not in HC. Administration of vitamin D may have a positive effect in CD by modulating the intestinal bacterial composition and also by increasing the abundance of potential beneficial bacterial strains.