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Polyethylene glycol‐based bowel preparation before colonoscopy for selected inpatients: A pilot study
Author(s) -
Pontone Stefano,
Palma Rossella,
Panetta Cristina,
Eberspacher Chiara,
Angelini Rita,
Pironi Daniele,
Filippini Angelo,
Pontone Paolo
Publication year - 2018
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12571
Subject(s) - medicine , colonoscopy , bowel preparation , group b , tolerability , peg ratio , gastroenterology , surgery , adverse effect , colorectal cancer , cancer , finance , economics
OBJECTIVE To evaluate the impact of a new same‐day, low‐dose 1‐L polyethylene glycol‐based (1‐L PEG) bowel preparation on the diagnostic rating of selected hospitalized patients and its tolerability, with risk factors for inadequate bowel preparation. METHODS A single‐center prospective pilot study was conducted with hospitalized patients scheduled for colonoscopy, presenting risk factors for poor bowel preparation, such as bleeding or subocclusive symptoms. The included patients were randomly divided in two groups, which received either a same‐day 1‐L PEG (group A) or a split‐dose 4‐L PEG (group B), and performed a colonoscopy within 4 h of the last dose. RESULTS In all, 44 inpatients [27 males; mean age 63.5 years (range 20–94 years)] were enrolled. Optimal bowel cleansing was reached in 64% and 55% ( P = 0.64) of patients in groups A and B, respectively. The adenoma detection rate was 14% (group A) and 18% (group B) ( P = 0.34). A valid diagnosis was reached in 38 (86%) of 44 patients (21 in group A and 17 in group B) after a mean hospitalization of 3 days for group A and 6 days for group B ( P = 0.04). CONCLUSIONS Our data support the conclusion that the schedule protocol proposed in this study enables a clear diagnosis in most of the inpatients at high risk of poor bowel preparation and no statistical differences were found between the two groups in terms of successful bowel cleansing achieved. Therefore, the same‐day, low‐dose 1‐L PEG bowel preparation could be introduced for selected inpatients.