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Clinical characteristics of ulcerative colitis‐related colorectal cancer in Chinese patients
Author(s) -
Wang Ya Nan,
Li Ji,
Zheng Wei Yang,
Wu Dong,
Yang Hong,
Li Yue,
Lv Hong,
Tan Bei,
Shu Hui Jun,
Sun Xi Yu,
Qian Jia Ming,
Wu Bin,
Li Jing Nan
Publication year - 2017
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12558
Subject(s) - medicine , ulcerative colitis , gastroenterology , colorectal cancer , incidence (geometry) , stage (stratigraphy) , adenocarcinoma , cancer , disease , family history , paleontology , physics , optics , biology
OBJECTIVE The prevalence of ulcerative colitis (UC) in China has been increasing, together with the incidence of ulcerative colitis‐related colorectal cancer (UCRCC). In this study we aimed to investigate the clinical features of UCRCC in Chinese UC patients. METHODS Clinical data of patients with UCRCC during January 2003 to December 2016 were retrieved from the Peking Union Medical College Hospital registration database and compared with that of sporadic colorectal cancer (CRC). RESULTS During the study period, among the 10 110 patients with CRC 25 were found to have UCRCC, with an average age of 51 years and a median disease duration of 15 years. The cumulative prevalence of UCRCC was 0.25% in all CRC patients, with a significant increase from 2003–2007 to 2013–2016 ( P < 0.01). Altogether 14 (56.0%) patients with UCRCC were men, and 5 (20.0%) had a family history of UC or cancer. Four (16.0%) patients had concurrent high‐grade intraepithelial neoplasia with variable differentiated adenocarcinoma at other sites and 19 (59.4%) tumors were moderately or poorly differentiated. Twenty‐three (92.0%) patients underwent surgery, of whom 10 (40%) were at stage III and IV according to the TNM staging system. Compared with the 10 085 patients with sporadic CRC, UCRCC patients were younger ( P < 0.01) and were more likely to have descending colon involvement and multifocal lesions ( P < 0.01). CONCLUSIONS UCRCC patients have been increasing in recent years. Compared with patients with sporadic CRC, those with UCRCC are younger and are more likely to have descending colon involvement and multifocality.