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The evaluation of non‐invasive multi‐slice spiral computed tomography‐based indices for the diagnosis and prognosis prediction of liver cirrhosis
Author(s) -
Feng Ling Mei,
Lei Shu Juan,
Zeng Xin,
Wang Pei Qin,
Chen Ru Tan,
Wang Jian,
Sheng Xia,
Shi Pei Mei,
Yuan Zong Li,
Xie Wei Fen
Publication year - 2017
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12506
Subject(s) - medicine , cirrhosis , receiver operating characteristic , spiral computed tomography , radiology , portal hypertension , computed tomography , gastroenterology , area under the curve
OBJECTIVE This study aimed to evaluate easily available computed tomography (CT)‐based parameters for assessing the presence and severity of cirrhosis and predicting complications in Chinese patients with cirrhosis. METHODS CT‐based morphological indices were determined in 167 patients with cirrhosis and 244 healthy volunteers. The correlation of morphological indices with Child–Pugh score and cirrhotic complications was analyzed using Spearman's correlation analysis. The area under the receiver operating characteristic curve (AUROC) was used to analyze the diagnostic performance of the indices. Sensitivity and specificity were determined. RESULTS Patients with cirrhosis had a lower total liver volume (TLV) and a larger total splenic volume (SV) than healthy individuals. There was a significant difference in the portal venous diameter, splenic venous diameter and portal venous cross‐sectional area between the two groups. A low TLV/SV ratio was strongly associated with liver cirrhosis; with a cut‐off value of 4.27 for the diagnosis of cirrhosis TLV/SV had a sensitivity of 87.7% and a specificity of 84.9%, and AUROC of 0.921. Further analysis showed that TLV/SV was accurate in discriminating between mild and moderate/severe cirrhosis and could be used for predicting complications of cirrhosis. CONCLUSION The easily available parameters of CT can accurately evaluate the severity of cirrhosis in Chinese patients.