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Association between non‐invasively diagnosed hepatic steatosis and chronic kidney disease in C hinese adults on their health check‐up
Author(s) -
Zeng Jing,
Sun Chao,
Sun Wan Lu,
Chen Guang Yu,
Pan Qin,
Yan Shi Yan,
Xu Zheng Jie,
Chen Yuan Wen,
Fan Jian Gao
Publication year - 2017
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12465
Subject(s) - medicine , fatty liver , kidney disease , odds ratio , steatosis , gastroenterology , renal function , diabetes mellitus , confidence interval , risk factor , disease , endocrinology
OBJECTIVE To explore the association between chronic kidney disease (CKD), graded by the estimated glomerular filtration rate (eGFR), and non‐alcoholic fatty liver disease (NAFLD) using controlled attenuation parameter (CAP) and fatty liver index (FLI) values in Chinese adults undergoing routine health examinations. METHODS A total of 731 adult participants without diabetes mellitus or significant alcohol consumption who underwent routine health examinations were included. Their eGFR, CAP, FLI and abdominal ultrasonography results were assessed. RESULTS The prevalence of ultrasound‐diagnosed NAFLD and CKD (eGFR <60 mL/min per 1.73 m 2 ) was 36.1% and 6.6%, respectively. CKD was more common in NAFLD patients than in those without (10.6% vs 4.3%, P < 0.001). The CAP and FLI values were significantly higher in the NAFLD group than in those without, but the change in the eGFR was negligible between the two groups. eGFR was negatively correlated with CAP ( r = −0.189, P = 0.003) and FLI values ( r = −0.130, P = 0.045). Moreover, eGFR was significantly lower in participants with CAP >292 dBm or FLI ≥60 than in those with CAP <238 dBm or FLI <30, respectively (both P < 0.05). The CAP value (odds ratio [OR] 1.099, 95% confidence interval [CI] 1.091–1.108, P = 0.021) was an independent risk factor for CKD. CONCLUSIONS A diagnosis of hepatic steatosis is related to an increased risk of CKD among non‐alcoholic and non‐diabetic Chinese adults regardless of whether the diagnosis was acquired via ultrasound, CAP or FLI. Increased hepatic lipid content may contribute to CKD development.