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Polyethylene glycol plus ascorbic acid is as effective as sodium picosulfate with magnesium citrate for bowel preparation: A randomized trial
Author(s) -
Choi HyunSeok,
Chung JunWon,
Lee Ji Won,
Lim Min Young,
Park Dong Kyun,
Kim Yoon Jae,
Kwon Kwang Ahn,
Kim Jung Ho
Publication year - 2016
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12337
Subject(s) - medicine , peg ratio , ascorbic acid , gastroenterology , nausea , randomized controlled trial , polyethylene glycol , adverse effect , regimen , cathartic , biochemistry , chemistry , finance , economics , food science
Objective This study was aimed to evaluate the efficacy and safety of two low‐volume agents, polyethylene glycol (PEG)‐3350 plus ascorbic acid (PEG + Asc) and sodium picosulfate with magnesium citrate (SPMC), for bowel preparation. Methods We performed a prospective, endoscopist‐blinded, single‐center, randomized controlled trial comparing PEG + Asc with SPMC to evaluate the bowel cleansing efficacy of the two regimens using the modified Ottawa bowel preparation scale (OBPS) and the Aronchick scale. Patients’ taste and overall tolerance were assessed with a questionnaire. Results In total, 200 patients were randomized to receive either PEG + Asc ( n = 98) or SPMC ( n = 102). Both treatments were similarly efficacious in bowel cleansing, based on the modified OBSP (PEG + Asc 4.01 ± 2.29 vs SPMC 3.86 ± 2.47, P = 0.62) and Aronchick scale (PEG + Asc 1.96 ± 0.70 vs SPMC 1.89 ± 0.70, P = 0.42). Patient‐reported taste and tolerance of each regimen, as reported by the questionnaire, were significantly greater in the PEG + Asc group than in the SPMC group ( P = 0.01). In terms of adverse events, dizziness was more frequently observed in the PEG + Asc group ( P = 0.03), whereas nausea was more common in the SPMC group ( P = 0.02). Conclusions PEG + Asc and SPMC show similar efficacy for bowel preparation. However, patient's overall tolerance is higher in the PEG + Asc group.