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Is gallstone disease associated with inflammatory bowel diseases? A meta‐analysis
Author(s) -
Zhang Fen Ming,
Xu Cheng Fu,
Shan Guo Dong,
Chen Hong Tan,
Xu Guo Qiang
Publication year - 2015
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12286
Subject(s) - medicine , publication bias , meta analysis , odds ratio , cochrane library , inflammatory bowel disease , confidence interval , subgroup analysis , gastroenterology , ulcerative colitis , medline , disease , political science , law
Objective To investigate the association between inflammatory bowel disease (IBD) and gallstone disease (GD) by performing a meta‐analysis. Methods PubMed, Medline, Embase, Web of Science and the Cochrane Library were searched for relevant articles published between January 1980 and February 2015. All statistical analyses were performed using STATA 12.0. A fixed‐effects model was adopted; heterogeneity was evaluated by χ 2 test and I 2 statistic; publication bias was assessed by Begg's and Egger's tests. Results Five studies qualified for inclusion in the meta‐analysis. Patients with IBD had a significantly higher prevalence of GD than those in the control group [odds ratio (OR) 1.72, 95% confidence interval (CI) 1.40–2.12, P < 0.0001]. Subgroup analyses showed a significantly higher prevalence of GD in patients with Crohn's disease (CD) (OR 2.05, 95% CI 1.61–2.63, P < 0.0001). However, no significant difference in the prevalence of GD was observed between patients with ulcerative colitis (UC) and controls (OR 1.12, 95% CI 0.75–1.68, P = 0.585). Studies from Italy, Sweden and the UK revealed a higher prevalence of GD in patients with IBD. No heterogeneity ( I 2 = 25.2%, P = 0.228) or publication bias was observed in our meta‐analysis (Begg's test, P = 0.711; Egger's test, P = 0.805). Conclusions Our meta‐analysis suggests there is a trend towards higher prevalence of GD in IBD patients, and especially in patients with CD. More rigorous, large‐scale multi‐center studies are required to investigate the association between GD and IBD.