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Vitamin D deficiency in patients with intestinal malabsorption syndromes – think in and outside the gut
Author(s) -
Margulies Samantha L,
Kurian Divya,
Elliott Mark S,
Han Zhiyong
Publication year - 2015
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12283
Subject(s) - malabsorption , medicine , vitamin d deficiency , inflammatory bowel disease , vitamin d and neurology , gastroenterology , disease , cystic fibrosis , population , pathogenesis , physiology , environmental health
There is a very high prevalence of vitamin D deficiency, which is defined by a serum level of 25‐hydroxyvitamin D [25(OH)D] of lower than 20 ng/mL, in all populations of the world. Unfortunately, the prevalence of vitamin D deficiency in patients with intestinal malabsorption syndromes, including cystic fibrosis (CF), celiac disease (CD), short bowel syndrome and inflammatory bowel disease (IBD), is higher than that in the general population, indicating the presence of disease‐specific causative factors. In this review, we aimed to present clinical findings to highlight the roles of insufficient exposure to sunlight and inflammation in the development of vitamin D deficiency in patients with intestinal malabsorption syndromes. Furthermore, we aimed to present experimental evidence that supported a role of vitamin D deficiency in the pathogenesis of IBD. Finally, we reviewed clinical intervention strategies aiming to normalize vitamin D status in and even to improve the conditions of patients and to discuss certain issues that needed to be addressed in future research.