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Risk factors for small bowel bleeding in chronic nonsteroidal anti‐inflammatory drug users
Author(s) -
Cho KyuMan,
Park SeonYoung,
Chung Jin Ook,
Jun ChungHwan,
Kim TaeJong,
Son DongJun,
Kim BanSuk,
Park ChangHwan,
Kim HyunSoo,
Choi SungKyu,
Rew JongSun
Publication year - 2015
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12269
Subject(s) - medicine , thienopyridine , rebamipide , odds ratio , confidence interval , logistic regression , coronary artery disease , enteropathy , aspirin , gastroenterology , clopidogrel , disease
Objective The incidence of nonsteroidal anti‐inflammatory drugs (NSAIDs)‐induced enteropathy is currently increasing. However, the predictors of small bowel bleeding ( SBB ) associated with NSAIDs are unknown. This study aimed to assess the risk factors of SBB in chronic NSAIDs users. Methods We retrospectively compared the medical records of 147 patients receiving NSAID s in a tertiary‐care setting (31 with SBB and 116 without previous bleeding events) and analyzed the predictors of SBB . Results In total, 31 patients underwent video capsule endoscopy to detect SBB , 74.2% of whom showed the evidence of SBB . Non‐invasive treatment was performed in 90.3% of the patients. Multivariate logistic regression analysis revealed that the presence of coronary artery disease [adjusted odds ratio (a OR ) 12.43, 95% confidence interval ( CI ) 1.19–130.34, P = 0.04], use of thienopyridine (aOR 16.93, 95% CI 3.78–75.72, P < 0.001) and prior use of rebamipide (a OR 0.31, 95% CI 0.12–0.82, P = 0.02) were independently associated with SBB in NSAIDs users. Conclusions Coronary artery disease and co‐use of thienopyridine were associated with SBB in NSAIDs users. The patients with coronary artery disease co‐using thienopyridine need to be monitored for the occurrence of SBB when they were prescribed with NSAID s.