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Overlap of gastroesophageal reflux disease and functional bowel disorders in the general Chinese rural population
Author(s) -
Cai Shun Tian,
Wang Li Ying,
Sun Gang,
Peng Li Hua,
Guo Xu,
Wang Wei Feng,
Yang Yun Sheng
Publication year - 2015
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12262
Subject(s) - gerd , medicine , odds ratio , population , gastroenterology , confidence interval , reflux , logistic regression , disease , cross sectional study , pathology , environmental health
Objective This study aimed to investigate the prevalence of the overlap between gastroesophageal reflux disease ( GERD ) and functional bowel disorders ( FBD ) in the general population in rural areas in C hina. Methods A population‐based cross‐sectional study was conducted in six villages in Nanmazhuang area in Lankao County (Henan Province, China) from D ecember 2010 to O ctober 2011. The GERD questionnaire (GerdQ) and Rome III criteria were used for the diagnosis of GERD and FBD and to determine the prevalence of GERD – FBD overlap. Results The response rate to the questionnaires of the patients was 91.5%. In all, 2950 of 3700 residents with a mean age of 42.4 ± 16.8 years were included. Among them, 4.8% were diagnosed with GERD and 4.6% with FBD . The proportion of respondents with FBD was significantly higher in the GERD group than that in the non‐ GERD group (25.53% vs 3.60%, P < 0.05). The prevalence of GERD in the FBD group was significantly higher than that in the non‐ FBD group (26.28% vs 3.73%, P < 0.05). The prevalence of GERD – FBD overlap in the general rural population was 1.22%. Logistic regression analysis indicated that anxiety was an independent predictor for the GERD‐FBD overlap in GERD and FBD (odds ratio [ OR] 1.05, 95% confidence interval [ CI] 1.02–1.09 and OR 1.06, 95% CI 1.02–1.10, respectively). Conclusion GERD ‐ FBD overlap is more common than expected by chance in the general rural population, and anxiety is significantly related to the overlap.