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Value of microwave ablation in treatment of large lesions of hepatocellular carcinoma
Author(s) -
Medhat Eman,
Abdel Aziz Ashraf,
Nabeel Mohammed,
Elbaz Tamer,
Zakaria Zeinab,
Shousha Hend,
Amer Ayman,
Fouad Fathalah Waleed,
Maher Rabab,
Musa Shereif
Publication year - 2015
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12259
Subject(s) - microwave ablation , medicine , hepatocellular carcinoma , ablation , percutaneous , tumor progression , radiology , lesion , surgery , ablative case , radiation therapy , cancer
Objective Thermal ablative therapies continue to be favored as a safe and effective treatment for patients with non‐resectable hepatocellular carcinoma ( HCC) . Percutaneous microwave ablative therapy, which is a relatively new technique, has the advantage in providing faster ablation of large tumors. This study aimed to evaluate microwave ablation in the treatment of large HCC (5–7 cm) and to assess its effect on local tumor progression, prognostic outcome and patients' survival. Methods In all, 26 patients with large HCC lesions (5–7 cm) were managed in the multidisciplinary clinic of K asr A l A iny U niversity hospital using microwave ablation. The treatment was performed with the patient under conscious sedation and analgesia and ultrasonography‐guided using an HS AMICA microwave machine operating at frequency of 2450 MHz and a power up to 100 W . Multiple needle insertions were made in one or two sessions according to the size of the lesion. The complete ablation rate, local tumor progression and patients' overall survival were analyzed, and the efficacy and safety of MWA was evaluated. Results Complete ablation was achieved in 19/26 (73.1%). Local tumor progression was recorded in five treated lesions (19.2%). Distant tumor progression within the liver was recorded in six patients (23.1%), with a mean survival of 21.5 months. No procedure‐related major complications or deaths were observed. Conclusions Percutaneous microwave ablation is safe and effective in the treatment of large HCC tumors. Patients' survival and local tumor control were acceptable.