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Application of AJCC / UICC and WHO ‐2010 classifications for GEP‐NEN in C hinese patients
Author(s) -
Ye Bi Xing,
Heng Ding,
Jiang Liu Qin,
Wang Yun,
Zhang Hong Jie,
Lin Lin
Publication year - 2015
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12239
Subject(s) - medicine , grading (engineering) , overall survival , stage (stratigraphy) , oncology , ajcc staging system , multivariate analysis , univariate analysis , cancer , gastroenterology , staging system , paleontology , civil engineering , engineering , biology
Objective To assess the prognostic value in C hinese patients of two new systems, the W orld H ealth O rganization ( WHO) ‐2010 and the A merican J oint C ommittee on C ancer and the U nion for I nternational C ancer C ontrol ( AJCC / UICC ) systems, for the classification of gastroenteropancreatic neuroendocrine neoplasms ( GEP‐NEN ). Methods One hundred and three patients with GEP‐NEN treated at the F irst A ffiliated H ospital of N anjing M edical U niversity from J anuary 2003 to D ecember 2011 were included in the study. All patients were diagnosed pathologically and had complete follow‐up data. Univariate and multivariate analyses of their clinicopathological characteristics were performed. Results The 5‐year survival rates were 95%, 74%, 24% and 15% based on the AJCC / UICC stages I to IV , and 92%, 62% and 29% according to WHO ‐2010 grades 1 to 3, respectively, in patients with GEP‐NEN. A higher mortality was observed in patients with AJCC / UICC stage III and IV tumors compared with those at stage I – II , and patients with stage II compared with those with stage I , whereas there was no difference in survival between stage IV and III patients. Based on the WHO ‐2010 grading classification, patients with grade 3 tumors had the lowest survival rate than those with grade 1 and 2 tumors, followed by patients with grade 2 tumors. Conclusion The WHO‐2010 and AJCC / UICC staging systems can effectively evaluate the prognosis of patients with GEP‐NEN , although the latter might not accurately discriminate the prognosis of patients with local metastasis from those having distant metastasis.