Premium
Effect of a common genetic variant microRNA ‐146a rs2910164 on colorectal cancer: A meta‐analysis
Author(s) -
Xie Wen Qun,
Tan Shi Yun,
Wang Xiao Fan
Publication year - 2014
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/1751-2980.12201
Subject(s) - meta analysis , medicine , odds ratio , confidence interval , colorectal cancer , subgroup analysis , genetic model , oncology , microrna , case control study , bioinformatics , cancer , genetics , gene , biology
Objective There is emerging evidence that the microRNA‐146a (mi R‐146a) rs2910164 polymorphism might be associated with the susceptibility to colorectal cancer (CRC). However, previous published studies have failed to achieve a definitive conclusion. We aimed to address this issue in an updated meta‐analysis.Methods A comprehensive literature search was conducted in PubMed , E mbase, C hina BioMedicine , the C ochrane L ibrary and G oogle S cholar to identify eligible studies. Case‐control studies written in English that evaluated the association between miR‐146a polymorphism and CRC were included. Odds ratio and 95% confidence interval were calculated in the quantitative synthesis. Results Overall seven case‐control studies including a total of 2978 cases and 3576 cancer‐free or healthy controls were enrolled in the meta‐analysis. The results indicated that there was no association between miR‐146a G/C rs2910164 polymorphism and CRC risk either in the overall analysis or among A sians, when stratified on the basis of ethnicity. Conclusion miR‐146a G / C genetic polymorphism was not related to the susceptibility to CRC.